Publications
STORM publications
Yaara Ofir-Rosenfeld, Lina Vasiliauskaitė, Joanna Obacz, Georgia Tsagkogeorga, Josefin-Beate Holz, Jerry McMahon and Oliver Rausch
N6-methyladenosine (m6A) is one of the most abundant RNA modifications, which influences mRNA and lncRNA localization, half-life, translation, and splicing.
STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses and synergises with immune checkpoint blockade
STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses associated with increased interferon signalling, and synergises with T cell checkpoint blockade
Medhi R, Price J, Furlan G, Gorges B, Sapetschnig A, Miska EA.
RNA. 2022 Mar;28(3):353-370. doi: 10.1261/rna.078976.121. Epub 2021 Dec 23.PMID: 34949722
Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, Pilka ES, Aspris D, Leggate D, Hendrick AG, Webster NA, Andrews B, Fosbeary R, Guest P, Irigoyen N, Eleftheriou M, Gozdecka M, Dias JML, Bannister AJ, Vick B, Jeremias I, Vassiliou GS, Rausch O, Tzelepis K, Kouzarides T.
Nature. 2021 May;593(7860):597-601. doi: 10.1038/s41586-021-03536-w. Epub 2021 Apr 26.PMID: 33902106
Bazaga A, Leggate D, Weisser H.
Sci Rep. 2020 Jul 1;10(1):10787. doi: 10.1038/s41598-020-67846-1.PMID: 32612205
Wein S, Andrews B, Sachsenberg T, Santos-Rosa H, Kohlbacher O, Kouzarides T, Garcia BA, Weisser H.
Nat Commun. 2020 Feb 17;11(1):926. doi: 10.1038/s41467-020-14665-7.PMID: 32066737
Tzelepis K, Rausch O, Kouzarides T.
Nat Struct Mol Biol. 2019 Oct;26(10):858-862. doi: 10.1038/s41594-019-0312-0. Epub 2019 Oct 3.PMID: 31582848
Barbieri I, Tzelepis K, Pandolfini L, Shi J, Millán-Zambrano G, Robson SC, Aspris D, Migliori V, Bannister AJ, Han N, De Braekeleer E, Ponstingl H, Hendrick A, Vakoc CR, Vassiliou GS, Kouzarides T.
Nature. 2017 Dec 7;552(7683):126-131. doi: 10.1038/nature24678. Epub 2017 Nov 27.PMID: 29186125
Other relevant publications
Alfonzo JD, Brown JA, Byers PH, Cheung VG, Maraia RJ, Ross RL.
Nat Genet. 2021 Aug;53(8):1113-1116. doi: 10.1038/s41588-021-00903-1.PMID: 34267373
Suzuki T.
Nat Rev Mol Cell Biol. 2021 Jun;22(6):375-392. doi: 10.1038/s41580-021-00342-0. Epub 2021 Mar 3.PMID: 33658722
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM.
EMBO J. 2020 Oct 15;39(20):e104514. doi: 10.15252/embj.2020104514. Epub 2020 Sep 23.PMID: 32964498
Barbieri I, Kouzarides T.
Nat Rev Cancer. 2020 Jun;20(6):303-322. doi: 10.1038/s41568-020-0253-2. Epub 2020 Apr 16.PMID: 32300195
Ishizuka JJ, Manguso RT, Cheruiyot CK, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP, Yates KB, Dubrot J, Buchumenski I, Comstock DE, Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ, Griffin GK, Collins NB, Long AH, Doench JG, Kozono D, Levanon EY, Haining WN.
Nature. 2019 Jan;565(7737):43-48. doi: 10.1038/s41586-018-0768-9. Epub 2018 Dec 17.PMID: 30559380
Ferron F, Decroly E, Selisko B, Canard B.
Antiviral Res. 2012 Oct;96(1):21-31. doi: 10.1016/j.antiviral.2012.07.007. Epub 2012 Jul 26.PMID: 22841701